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The book Big Heart Healing a Multidimensional Approach to Trauma and Abuse brings forty years’ of experience as a physician, psychiatrist, psychotherapist and spiritual healer to bear on fundamental issues regarding the nature of human reality in general and the integrative treatment of severe childhood abuse in particular. I have spent my entire adult life exploring the mysteries of psychology, psychiatry
and spirituality and using what I have learned to help patients and
other seekers I meet on the path. Each step along the way I have approached each new frontier with as much curiosity and openness as I could muster and have integrated what I have experienced into previous understanding by expanding my perspective to be more inclusive.
By my very nature I am an integrator, responding to each experience by
widening my perspective rather than excluding what doesn’t fit into a previously held theory or belief system. This lifelong habit of integration has never been easy. Uncomfortable periods of confusion over conflicting frames of reference are hard to endure, not knowing how long it will take until I get a glimpse of the larger reality which embraces both. I have gone in and out of this chaotic condition a number of times, always arriving at an expanded perspective eventually, but never more dramatically than during the five years leading up to the work described in the book.

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The Professional Guinea Pig: Big Pharma and the Risky World of Human Subjects Description

The Professional Guinea Pig documents the emergence of the professional research subject in Phase I clinical trials testing the safety of drugs in development. Until the mid-1970s Phase I trials were conducted on prisoners. After that practice was outlawed, the pharmaceutical industry needed a replacement population and began to aggressively recruit healthy, paid subjects, some of whom came to depend on the income, earning their living by continuously taking part in these trials. Drawing on ethnographic research among self-identified “professional guinea pigs" in Philadelphia, Roberto Abadie examines their experiences and views on the conduct of the trials and the risks they assume by participating. Some of the research subjects he met had taken part in more than eighty Phase I trials. While the professional guinea pigs tended to believe that most clinical trials pose only a moderate health risk, Abadie contends that the hazards presented by continuous participation, such as exposure to potentially dangerous drug interactions, are discounted or ignored by research subjects in need of money. The risks to professional guinea pigs are also disregarded by the pharmaceutical industry, which has become dependent on the routine participation of experienced research subjects. Arguing that financial incentives compromise the ethical imperative for informed consent to be freely given by clinical-trials subjects, Abadie confirms the need to reform policies regulating the participation of paid subjects in Phase I clinical trials.