The Agile Approach to Adaptive Research: Optimizing Efficiency in Clinical Development (Wiley Series on Technologies for the Pharmaceutical Industry) Best Reviews

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Apply adaptive research to improve results in drug development

The pharmaceutical industry today faces a deepening crisis: inefficiency in its core business, the development of new drugs. The Agile Approach to Adaptive Research offers a solution. It outlines how adaptive research, using already-available tools and techniques, can enable the industry to streamline clinical trials and reach decision points faster and more efficiently.

With a wealth of real-world cases and examples, author Michael Rosenberg gives readers a practical overview of drug development, the problems inherent in current practices, and the advantages of adaptive research technology and methods. He explains the concepts, principles, and specific techniques of adaptive research, and demonstrates why it is an essential evolutionary step toward improving drug research and development.

Chapters explore such subjects as:

• The adaptive concept

• Design and operational adaptations

• Sample-size reestimation

• Agile clinical development

• Safety and dose finding

• Statistics in adaptive research, including frequentist and Bayesian approaches

• Data management technologies

• The future of clinical development

By combining centuries-old intellectual foundations, recent technological advances, and modern management techniques, adaptive research preserves the integrity and validity of clinical research but dramatically improves efficiency.

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Health Care Research Done Right: A Journal Editor Shares Practical Tips and Techniques for High Quality and Efficiency Top Reviews

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High Quality and Efficiency—You Can Have Both!

Are you a health care researcher or student who is long on objectives but short on time? Do you think that you have to choose between “doing it fast" and “doing it right"? Or do you use health care research information but feel unsure about whether it is accurate? This book was designed with your needs in mind. Written in an entertaining style by an experienced journal editor and methodologist, the book is a wealth of practical tips that one reviewer has called “a unique and welcome breath of fresh air." Learn how to:

• Plan your research well at the start to avoid problems later in the process
• Organize data files to improve accuracy and save time
• Avoid common mathematical mistakes
• Use health care claims databases effectively by understanding their strengths and limitations
• Conduct a survey that yields valuable information
• Write a publishable article
• Respond appropriately to peer reviewer comments even when they are incorrect
• Assess the quality of research evidence …
and more!
Kathleen A. Fairman is a journal editor, principal investigator, and author with 25 years of experience in evaluating public and private-sector health care programs. With a passion for encouraging researchers to pursue excellence, she shares vital insights about why research methods—those seemingly mundane study details that are sometimes overlooked—matter deeply to the welfare of patients served by the health care system. Readers will benefit greatly from her wisdom, grace, and humor—and find that good research methodology can be both practical and fun.



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Health Care Research Done Right: A Journal Editor Shares Practical Tips and Techniques for High Quality and Efficiency Feature