+++ Biostatistical Methods: The Assessment of Relative Risks (Wiley Series in Probability and Statistics)

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Praise for the First Edition

". . . an excellent textbook . . . an indispensable reference for biostatisticians and epidemiologists."
—International Statistical Institute

A new edition of the definitive guide to classical and modern methods of biostatistics

Biostatistics consists of various quantitative techniques that are essential to the description and evaluation of relationships among biologic and medical phenomena. Biostatistical Methods: The Assessment of Relative Risks, Second Edition develops basic concepts and derives an expanded array of biostatistical methods through the application of both classical statistical tools and more modern likelihood-based theories. With its fluid and balanced presentation, the book guides readers through the important statistical methods for the assessment of absolute and relative risks in epidemiologic studies and clinical trials with categorical, count, and event-time data.

Presenting a broad scope of coverage and the latest research on the topic, the author begins with categorical data analysis methods for cross-sectional, prospective, and retrospective studies of binary, polychotomous, and ordinal data. Subsequent chapters present modern model-based approaches that include unconditional and conditional logistic regression; Poisson and negative binomial models for count data; and the analysis of event-time data including the Cox proportional hazards model and its generalizations. The book now includes an introduction to mixed models with fixed and random effects as well as expanded methods for evaluation of sample size and power. Additional new topics featured in this Second Edition include:

• Establishing equivalence and non-inferiority
• Methods for the analysis of polychotomous and ordinal data, including matched data and the Kappa agreement index
• Multinomial logistic for polychotomous data and proportional odds models for ordinal data
• Negative binomial models for count data as an alternative to the Poisson model
• GEE models for the analysis of longitudinal repeated measures and multivariate observations

Throughout the book, SAS is utilized to illustrate applications to numerous real-world examples and case studies. A related website features all the data used in examples and problem sets along with the author's SAS routines.

Biostatistical Methods, Second Edition is an excellent book for biostatistics courses at the graduate level. It is also an invaluable reference for biostatisticians, applied statisticians, and epidemiologists.

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+++ Best Revews Wood Dust and Formaldehyde (IARC Monographs on the Evaluation of the Carcinogenic Risks to Humans)

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Evaluates the carcinogenic risk to humans posed by occupational exposures to wood dust and formaldehyde. A number of occupational situations that involve exposure to wood dust also entail exposure to formaldehyde, as in plywood and particle board manufacture, during furniture and cabinet-making, and during parquet floor sanding and varnishing.
The carcinogenic risks of wood dust are evaluated in the first monograph. The highest occupational exposures were noted to occur in wood furniture and cabinet manufacture, especially during machine sanding and similar operations, in the finishing departments of plywood and particle-board mills, and in the workroom air of sawmills and planer mills near chippers, saws, and planers. Citing findings from several recent well-designed case-control studies, the monograph concludes that occupational exposure to wood dust is causally related to adenocarcinoma of the nasal cavities and paranasal sinuses. The evaluation further concluded that the excess risk of cancer is attributable to wood dust per se, rather than to other exposures in the workplace. Wood dust was classified as carcinogenic to humans.
Cancer risk associated with occupational exposure to formaldehyde is assessed in the second monograph. The assessment draws on findings from several cohort and case-control investigations of the relationship between exposure to formaldehyde and cancer of the oral cavity, pharynx, and respiratory tract. Citing inconsistencies in the reported results, the monograph concludes that these epidemiological studies can do no more than suggest a causal role of occupational exposure to formaldehyde in carcinoma of the nasal cavities and paranasal sinuses. The review found no evidence of excess risk for oropharyngeal, laryngeal or lung cancer among exposed workers. Several studies in which formaldehyde was administered to rats by inhalation showed evidence of carcinogenicity. Similar studies in hamsters showed no evidence of carcinogenicity, and studies in mice either showed no effect or were inadequate for evaluation. In rats administered formaldehyde in drinking-water, increased incidences were seen of forestomach papillomas in one study and of leukemias and gastrointestinal tract tumors in another; two other studies gave negative results. Formaldehyde was classified as probably carcinogenic to humans.

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+++ The Illusion of Certainty: Health Benefits and Risks

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The Illusion of Certainty: Health Benefits and Risks peels away the "veneer of certainty" which many of us attach to health risk and benefit information given to us in our daily lives. It was written and designed primarily to assist the public in comprehending and interpreting the uncertainty associated with the overwhelming amount of information on medical and environmental health risks. The book uses unique, visual presentations and case studies to explain the benefits of medical screening tests (e.g., mammography, prostate and colorectal cancer screening, cholesterol screening) and drugs (e.g., statins, Vioxx™) and the risks associated with exposure to environmental contaminants (e.g., lead, dioxin, radon). This book will help patients and their families get more involved in making medical decisions, and citizens face critical questions about the environment. By putting the complexities of risk analysis in terms the general public can relate to, the authors are empowering people to make well-informed decisions.

About the Authors:

Erik Rifkin is the president of an environmental consulting firm that specializes in the characterization of ecological and human health risks from exposure to soil, water, air and sediments. His firm provides assistance and guidance to federal and state regulatory agencies and corporations regarding the nature and magnitude of environmental risks and potential remediation strategies. Dr. Rifkin's broad experience includes the communication of health risks and benefits to groups concerned with these issues.

Edward J. Bouwer is Professor of Environmental Engineering at Johns Hopkins University in Baltimore, Maryland. He has extensive experience with water and soil pollution and treatment. His research provides guidance on defining and managing environmental risks and how to interpret human and ecological health risk data. Dr. Bouwer has served on several National Research Council committees that provide guidance on managing human and ecological risk

Guest Author Bob Sheff, MD, received his medical training as a radiologist at UCLA and Johns Hopkins Medical Center. He spent his career praticing medicine and running one of the largest medical managed-care systems in the U.S. Now semi-retired, he devotes his time to helping non-profit organizations and individual people address their medical concerns. He lives in Columbia, Maryland.

Written for: Undergraduate, graduate, medical and nursing students, engineers, government advisory agencies, research scientists, lawyers, politicians and anyone interested in risk analysis and the interpretation of risk values.

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