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Praise for the First Edition

". . . an excellent textbook . . . an indispensable reference for biostatisticians and epidemiologists."
—International Statistical Institute

A new edition of the definitive guide to classical and modern methods of biostatistics

Biostatistics consists of various quantitative techniques that are essential to the description and evaluation of relationships among biologic and medical phenomena. Biostatistical Methods: The Assessment of Relative Risks, Second Edition develops basic concepts and derives an expanded array of biostatistical methods through the application of both classical statistical tools and more modern likelihood-based theories. With its fluid and balanced presentation, the book guides readers through the important statistical methods for the assessment of absolute and relative risks in epidemiologic studies and clinical trials with categorical, count, and event-time data.

Presenting a broad scope of coverage and the latest research on the topic, the author begins with categorical data analysis methods for cross-sectional, prospective, and retrospective studies of binary, polychotomous, and ordinal data. Subsequent chapters present modern model-based approaches that include unconditional and conditional logistic regression; Poisson and negative binomial models for count data; and the analysis of event-time data including the Cox proportional hazards model and its generalizations. The book now includes an introduction to mixed models with fixed and random effects as well as expanded methods for evaluation of sample size and power. Additional new topics featured in this Second Edition include:

• Establishing equivalence and non-inferiority
• Methods for the analysis of polychotomous and ordinal data, including matched data and the Kappa agreement index
• Multinomial logistic for polychotomous data and proportional odds models for ordinal data
• Negative binomial models for count data as an alternative to the Poisson model
• GEE models for the analysis of longitudinal repeated measures and multivariate observations

Throughout the book, SAS is utilized to illustrate applications to numerous real-world examples and case studies. A related website features all the data used in examples and problem sets along with the author's SAS routines.

Biostatistical Methods, Second Edition is an excellent book for biostatistics courses at the graduate level. It is also an invaluable reference for biostatisticians, applied statisticians, and epidemiologists.

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Quality of life studies form an essential part of the evaluation of any treatment. Written by two authors who are well respected within this field, Quality of Life: The Assessment, Analysis and Interpretation of Patient-reported Outcomes, Second Edition lays down guidelines on assessing, analysing and interpreting quality of life data. The new edition of this standard book has been completely revised, updated and expanded to reflect many methodological developments emerged since the publication of the first edition.

• Covers the design of instruments, the practical aspects of implementing assessment, the analyses of the data, and the interpretation of the results
• Presents all essential information on Quality of Life Research in one comprehensive volume
• Explains the use of qualitative and quantitative methods, including the application of basic statistical methods
• Includes copious practical examples
• Fills a need in a rapidly growing area of interest
• New edition accommodates significant methodological developments, and includes chapters on computer adaptive testing and item banking, choosing an instrument, systematic reviews and meta analysis

This book is of interest for everyone involved in quality of life research, and it is applicable to medical and non-medical, statistical and non-statistical readers. It is of particular relevance for clinical and biomedical researchers within both the pharmaceutical industry and practitioners in the fields of cancer and other chronic diseases.

Reviews of the First Edition – Winner of the first prize in the Basis of Medicine Category of the BMA Medical Book Competition 2001:

“This book is highly recommended to clinicians who are actively involved in the planning, analysis and publication of QoL research." CLINICAL ONCOLOGY

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'Winner of first prize in the Basis of Medicine Category of the BMA Medical Book Competition 2001'

The One Essential Comprehensive Volume on Quality of Life Research. Quality of life studies are now an essential part of the evaluation of any treatment. Written by two authors who are well respected within this field, this book is the first volume to lay down guidelines on assessing, analysing and interpreting quality of life data.

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• Has a clear structure and consistent approach to the material covered

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What is the relationship between health, human nature, and human needs?
The impact of social change on communities?
The processes by which communities confront and overcome their health problems?
How do we study these health questions in new communities and become advocates for change?

These are critical questions in confronting the social causes of ill health, yet many health students do not have the appropriate training in the anthropological methods and techniques that help answer them. Christie Kiefer has written Doing Health Anthropology to prompt students to enter the community already prepared in these methods so that they can accurately ask and solve these important questions themselves.

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With the help of this text, practitioners and students alike will be able to integrate cultural anthropology methods of research into their health science investigations and community health initiatives.

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