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...the definitive tome on evidenced-based medicine... uniquely organized for an intuitive learning experience. Offers in-depth expansion of methodology, stats, and cost issues that emerge in medical research. (Book/CD)

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Crystallography Made Crystal Clear, Second Edition: A Guide for Users of Macromolecular Models (Complementary Science) Reviews

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Macromolecules are the proteins and nucleic acids upon which life depends. Understanding the action of biological macromolecules (giant molecules) requires detailed knowledge of their structures. Most of the more than ten thousand known structures of protein and nucleic acids were obtained by x-ray crystallography, the standard mechanism for determining protein structure. Essentially, proteins are frozen into rigid crystals, which can be stacked up in a repeating pattern--like supermarket displays. The structure of each individual crystal can be determined by the way x-rays are bent when they pass through the composite crystal. Protein structure is essential when investigating protein interactions and planning drug development.
Crystallography Made Crystal Clear, Second Edition explains how scientists discover the structures of the macromolecules. Scientists do not see these molecules directly. Instead, they build models as a means of interpreting data from x-ray diffraction by crystals, or by irradiation by other forms of energy. Users of these models need to know how they are obtained in order to know what they are seeing when they study a model of a macromolecule. They also need to know how to judge whether conclusions they draw from the molecular models are really supported by the models. This book uses visual and geometric models to help readers understand the mathematics that forms the basis of x-ray crystallography.
The field of protein crystallography is growing every day and has been instrumental in discovering the molecular principles of biology and in discovering new drugs, such as the recent protease inhibitors for AIDS. The field includes the largest percentage of Nobel prizes than any other scientific discipline. Every major university and drug company has a protein crystallography laboratory and this book is an invaluable aid to those wishing to practice protein crystallography
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* Provides clear, understandable descriptions of principles of X-ray crystallography
* Leads reader through unintimidating and thorough explanations of the underlying mathematics
* Provides abundant illustrations, including diagrams, charts, photographs, and color stereo
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* Includes brief descriptions of other diffraction methods (neutron, electron, Laue) and the kinds
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* Introduces other methods of macromolecular structure determination (NMR spectroscopy and
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Product Description : Crystallography Made Crystal Clear, Second Edition: A Guide for Users of Macromolecular Models (Complementary Science)

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Users' Guides to the Medical Literature: Essentials of Evidence-Based Clinical Practice Description

Evidence-Based Medicine. From the popular Users' Guides series in JAMA come two state-of-the-art books edited by Drs Gordon Guyatt and Drummond Rennie, with contributions from more than fifty of the most renowned evidence-based medicine (EBM) educators and practitioners in the world. As the culmination of nearly two decades of teaching and research, both of the Users' Guides to the Medical Literature provide the most detailed yet clinician-friendly exposition of the concepts necessary to use the medical literature to solve patient problems. Explore both text and CD-ROM of Users' Guides to the Medical Literature to learn: Why framing the right question is so important How to find and distinguish between strong and weak evidence What's needed to critically appraise the best evidence How to weigh the risks and benefits that precede medical management decisions How to individualize evidence to each patient The Essential EBM Toolkits. Together with the practical glossary, index, appendix of calculations, and laminated quick reference cards, each Users' Guides to the Medical Literature book and CD-ROM constitutes a comprehensive toolkit to support a clinical rounds presentation on evidence-based medicine. CD-ROM (included FREE with either text). Fully hyperlinked and searchable text and graphics Organized, classified, and coded to support electronic outlining, content filtering, and full-text searching Alternative content organizations allow for nonlinear learning experiences Free Access to Interactive Web Site With your purchase of the Users' Guides, you also get an initial free trial subscription to the Users' Guides Interactive Web site at www.usersguides.org . This interactive Web site includes the full text of Users' Guides, alternative browsing paths, references that are hyperlinked to NLM PubMed entries, collections of tips and reminders, interactive worksheets, and additional case scenarios. The Users' Guides Interactive