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Intervention Research

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"Intervention Research" Feature

2012 First Place AJN Book of the Year Award Winner in Nursing Research!

This book is a practical, user-friendly guide for health care researchers across multiple disciplines who are involved in intervention research. It provides all of the essential elements needed for understanding how to design, conduct, analyze, and fund intervention studies that are replicable and can withstand the scrutiny of the Institutional Review Board and peer review. Developed from an annual continuing education workshop on intervention studies conducted by Dr. Melnyk, this text is the most comprehensive body of information available on this topic.

Contributors address the design of interventions that are ethically considerate and sensitive to culture, race/ethnicity, and gender, minimizing threats to external and internal validity, measurement, and budgeting. The guide explores such implementation issues as subject recruitment and retention, data management, and specialized settings, cost analysis, and explaining intervention effects. The text also guides readers in writing grant applications that fund , and addresses how to move intervention study findings into the real world. A unique addition to the book is the availability of digital examples of progress reports, final reports, and research grant applications that have received funding from the National Institutes of Health and other relevant organizations. This text is a valuable resource for all health care professionals conducting research and for doctoral students in health care studies.

Key Features:

• Presents the essential tools for designing, conducting, analyzing, and funding intervention studies
• Designed for use by health care professionals conducting intervention research
• Provides comprehensive, accessible guidelines for doctoral students across all health care disciplines
• Instructs readers on writing grant applications that fund
• Includes digital examples of funded research grants, progress reports, and final reports
  
  
  
  
  
  
  
  
  

****** Save Deterministic And Stochastic Models Of Aids Epidemics And Hiv Infections With Intervention

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Deterministic And Stochastic Models Of Aids Epidemics And Hiv Infections With Intervention Description

With contributions from an international team of leading researchers, the book pulls together updated research results in the area of HIV/AIDS modeling to provide readers with the latest information in the field. Topics covered include: AIDS epidemic models; vaccine models; models for HIV/cell dynamics and interactions; cellular kinetics; viral dynamics with antiviral treatments; modeling of drug resistance and quasispecies. Extensive deterministic models, statistical models, stochastic models and state space models on treating AIDS patients with anti-retroviral drugs are provided, as well as an in-depth discussion of these models. The book also contains updated reviews on mathematical models for assessing effects of AIDS vaccines, statistical methods for analyzing clinical trial data on AIDS vaccines, and overviews of models and statistical methods for assessing drug resistance of HIV to anti- retroviral drugs. Some important statistical methods specific to the intervention and prevention of HIV epidemic are also discussed. This will be a useful reference source for graduate students and researchers in biomathematics and biostatistics, as well as for HIV/AIDS epidemiologists and clinical investigators learning quantitative methods to study AIDS epidemics and HIV infection.

****** Save The Gravity of JUPITER (Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin) (Postgraduate Medicine)

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The Gravity of JUPITER (Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin) (Postgraduate Medicine) Description

In the recently published Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) study, a large randomized, placebo-controlled trial, rosuvastatin proved to be safe and remarkably effective in the setting of primary prevention. In patients without coronary heart disease or diabetes, with a baseline low-density lipoprotein cholesterol (LDL-C) level < 130 mg/dL and a C-reactive protein (CRP) ≥ 2 mg/L, a statin-induced LDL-C reduction of 50% reduced serious cardiac events by about 50%, including in women and the elderly, and also lowered all-cause mortality. The mean on-treatment LDL-C level (55 mg/dL) in the rosuvastatin arm of JUPITER was about in the mid-range of the physiologically normal levels. C-reactive protein screening should be considered, especially in patients without preexisting indications for statin therapy. In general, the CRP-lowering efficacy of statin therapy is directly and significantly correlated with its LDL-C–lowering activity. Simvastatin, at the 80-mg daily dose, is more toxic to muscles and liver than other statins at their highest dose, and thus should be used with caution.

Original Publication Date: May 2009