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For the last 150 years, industrial, agricultural and household chemicals have been tested on animals for the alleged purpose of protecting the public from their dangerous effects. Through a meticulous analysis of the technical and scientific problems that have plagued animal tests for decades, this book reveals that using animals as human surrogates is not only unethical, it is bad science.

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As the stream of hi-tech drugs continues to multiply and a huge number of animals are used in medical experiments, debate continues about reliable methods for biomedical research and their adequacy in protecting human health from new products and procedures. In this book, a leading Italian medical researcher concludes, after years of himself practicing animal experimentation and vivisection, that the traditional reliance on these techniques is scientifically misplaced. Now available in a completely revised and updated English edition, Dr. Croce's classic work constitutes a powerful argument. He documents with a wealth of fascinating detail precisely how the scientific anti-vivisection movement has constructed a rational case, as opposed to a sentimental or ethical argument. He highlights the increasing dangers to human health resulting from the animal experimenters' assumption that the biological systems of humans and other species are sufficiently similar for valid biomedical comparison. And for the medical researcher, he provides an introduction to the range of alternative methods, including epidemiological research, computer simulation and in vitro techniques.

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In today's rapidly changing world of clinical practice, old assumptions quickly fall under the weight of new evidence. But to make effective clinical decisions, you must face a deluge of data published in the health research literature.

With this best-selling text as your guide, you'll discover a concise, stepwise program that will help you evaluate clinical studies, identify flaws in study design, interpret statistics, and apply evidence from clinical research to your practice.

Sharpen your analytical skills with these insightful features...

• Step-by-step approach ideal for both students and practitioners guides you through the health research literature, showing you the ingredients that go into a meaningful study, clues to potential study flaws, and ways to apply solid evidence in clinical practice.
• Uniform framework uses a simple six-point framework based on the mnemonic M.A.A.R.I.E. You will learn to evaluate studies in terms of Methods, Assignment, Assessment, Results, Interpretation, and Extrapolation.
• Hypothetical illustrations demonstrate the limitations of today's published studies.
• Unique learning aids—including question checklists, scenarios illustrating study design, and flaw-catching exercises—help you reinforce key facts and retain what you've learned.

NEW to the Fifth Edition...

• New "Guide to the Guidelines" section helps you make sense of established and emerging clinical guidelines, and helps you understand the role of these guidelines in practice.
• Current information on outcomes includes discussions of safety and of the effects of interactions on outcomes.
• More graphic presentation of statistics helps make complex concepts easy to grasp and apply using a flowchart of statistics.
• StudyingaStudy.com Website is an integral feature of this edition providing interactive materials for all sections of the book. The Website provides practice using the M.A.A.R.I.E. framework, interactive flaw-catching and Selecting a Statistics exercises, self-testing questions-answers and exercises using abstracts from real articles.
• Courses and Journal Clubs can now use Studying a Study and Testing a Test with the help of a special section of the Website.

Clear the path to a new understanding of evidence-based medicine...and integrate today's best evidence into tomorrow's practice. Order your copy of Studying a Study and Testing a Test, Fifth Edition today!

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How do we know whether a particular treatment really works? How reliable is the evidence? And how do we ensure that research into medical treatments best meets the needs of patients? These are just a few of the questions addressed in a lively and informative way in Testing Treatments. Brimming with vivid examples, Testing Treatments will inspire both patients and professionals. Building on the success of the first edition, Testing Treatments has now been extensively revised and updated. The Second Edition includes a thought-provoking chapter on screening, explaining why early diagnosis is not always better. Other new chapters explore how over-regulation of research can work against the best interests of patients, and how robust evidence from research can be drawn together to shape the practice of healthcare in ways that allow treatment decisions to be reached jointly by patients and clinicians. Testing Treatments urges everyone to get involved in improving current research and future treatment, and outlines practical steps that patients and doctors can take together.

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Ideal for clinical students including medical, nursing, pharmacy, dental, physician assistant and more!

Evidence-based information plays a critical role in clinical practice decisions. Secondary sources are often unreliable; it’s up to the student, then, to critically assess peer-reviewed research literature. Using a highly structured yet accessible method, this best-selling text teaches students to critically analyze research from primary sources.

Step-by-step approach– learn to recognize a meaningful study, clues to potential study flaws, and ways to apply solid evidence in clinical practice

Simple 6-point framework– learn to evaluate studies in terms of the author’s trademark mnemonic device, M.A.A.R.I.E. (Methods, Assignment, Assessment, Results, Interpretation and Extrapolation)