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The Quest for Cortisone

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"The Quest for Cortisone" Feature

In 1948, when “Mrs. G.," hospitalized with debilitating rheumatoid arthritis, became the first person to receive a mysterious new compound — cortisone — her physicians were awestruck by her transformation from enervated to energized. After eighteen years of biochemical research, the most intensively hunted biological agent of all time had finally been isolated, identified, synthesized, and put to the test. And it worked. But the discovery of a long-sought “magic bullet" came at an unanticipated cost in the form of strange side effects. This fascinating history recounts the discovery of cortisone and pulls the curtain back on the peculiar cast of characters responsible for its advent, including two enigmatic scientists, Edward Kendall and Philip Hench, who went on to receive the Nobel Prize. The book also explores the key role the Mayo Clinic played in fostering cortisone’s development, and looks at drugs that owe their heritage to the so-called “King of Steroids."

$$$$$ Tracking Medicine:A Researcher's Quest to Understand Health Care

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Written by a groundbreaking figure of modern medical study, Tracking Medicine is an eye-opening introduction to the science of health care delivery, as well as a powerful argument for its relevance in shaping the future of our country. An indispensable resource for those involved in public health and health policy, this book uses Dr. Wennberg's pioneering research to provide a framework for understanding the health care crisis; and outlines a roadmap for real change in the future. It is also a useful tool for anyone interested in understanding and forming their own opinion on the current debate.

****** Best Revews The Cure: How a Father Raised $100 Million--and Bucked the Medical Establishment--in a Quest to Save His Children

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The Cure: How a Father Raised $100 Million--and Bucked the Medical Establishment--in a Quest to Save His Children Description

“Amazing….Explores human courage under the most trying circumstances." —New York Post

 

“An inspirational story about business, medical science, and one father’s refusal to give up hope." —Boston Globe

 

The book that inspired the movie, Extraordinary Measures, starring Harrison Ford, Brendan Fraser, and Keri Russell, The Cure by Pulitzer Prize-winning journalist Geeta Anand is the remarkable true story of one father’s determination to find a cure for his terminally sick children even if it meant he had to build a business from scratch to do so. At once a riveting story of the birth of an enterprise—ala Tracy Kidder’s The Soul of a New Machine—and a inspiring tale of the indomitable human spirit in the vein of Erin Brockovich and A Civil Action, The Cure is a testament to ingenuity, unflagging will, and unconquerable love.

Human Trials: Scientists, Investors, And Patients In The Quest For A Cure Shopping

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Susan Quinn's extraordinary story takes the reader into the closed world of experimental "human trials" in which new drugs are developed. Both the portrait of a dedicated scientist and the archetypal story of all medical research, Human Trials is the emotion-laden, roller-coaster trip from the lab bench to the medicine cabinet, in which scientists risk their reputations, venture capitalists their millions, and patients their very lives. A Merloyd Lawrence Book

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****** Best Revews The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

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The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines Description

After more than fifty years of blockbuster drug development, skeptics are beginning to fear we are reaching the end of drug discovery to combat major diseases. In this engaging book, Brent R. Stockwell, a leading researcher in the exciting new science of chemical biology, describes this dilemma and the powerful techniques that may bring drug research into the twenty-first century.

Filled with absorbing stories of breakthroughs, this book begins with the scientific achievements of the twentieth century that led to today's drug innovations. We learn how the invention of mustard gas in World War I led to early anti-cancer agents and how the efforts to decode the human genome might lead to new approaches in drug design. Stockwell then turns to the seemingly incurable diseases we face today, such as Alzheimer's, many cancers, and others with no truly effective medicines, and details the cellular and molecular barriers thwarting scientists equipped with only the tools of traditional pharmaceutical research.

Scientists such as Stockwell are now developing methods to combat these complexities—technologies for constructing and testing millions of drug candidates, sophisticated computational modeling, and entirely new classes of drug molecules—all with an eye toward solving the most profound mysteries of living systems and finding cures for intractable diseases. If successful, these methods will unlock a vast terrain of untapped drug targets that could lead to a bounty of breakthrough medicines. Offering a rare, behind-the-scenes look at this cutting-edge research, The Quest for the Cure tells a thrilling story of science, persistence, and the quest to develop a new generation of cures.

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A small cadre of scientists—collaborators and competitors—are determined to develop a vaccine for malaria—a feat most tropical disease experts have long considered impossible. Skepticism, doubt, and a host of logistical and financial obstacles dog their quest. Success may ultimately elude them. Why, and how, do they persist?

Bill Shore is a writer, philanthropist, and business leader who knows from personal experience the rare and elusive nature of transformative innovation. In this moving and inspiring book, the story of these uncompromising scientists serves as springboard for his passionate inquiry into the character and moral fabric of those who devote their lives to solving the world’s most pressing and perplexing problems. What does it take to achieve the impossible? It takes whatever it takes.

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